Solid Microspheres

PLGA microspheres, 50um in diameter, produced using ink-jet technology and loaded with Paclitaxel.

The manufacturing procedure did not affect the pharmacological efficacy of the encapsulated drug, as indicated by HPLC chromatograms and confirmed by tissue culture assay (figure below).

Comparisons of standard Paclitaxel and Paclitaxel extracted from the fabricated microspheres. Top: HPLC comparison. Bottom: Tissue culture comparison.

Jetted microspheres displayed a sustained release for at least 50 days. The in vitro released amounts were in a range proven to be adequate for inhibition and reversal of tumor growth.

Release kinetics results.