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Press Release Plano, Texas (September 19, 2003) MicroFab Technologies today announced the award of a NIH Phase II SBIR program titled, “LC Microdispenser for High Resolution MALDI-TOF Analysis”. The objective of this project is to develop a microdispenser system for rapid liquid chromatography separation and high throughput loading of digested protein samples onto MALDI-TOF MS targets, such as for purpose of peptide mass fingerprinting. This system will incorporate a reversed phase column within the microdispensing device. This system will provide for the maximum conservation of sample volume combined with the rapid fractionation of peptides, resulting in improved MALDI-TOF MS analysis through a reduction in ion suppression. The function and sensitivity of the LC Microdispenser system will be verified by comparing the results of peptide mass fingerprinting to database information, such as SWISS-PROT. Commercialization efforts will be conducted in parallel with the research efforts, in collaboration with our commercialization partners: Proteome Systems, Shimadzu Biotech, and Millipore. MicroFab Technologies, Inc. under the supervision of the principal investigator, Dr. David Wallace, will develop and optimize the incorporation of the liquid chromatography columns within the ink-jet devices. The liquid chromatography ink-jet devices will be integrated into an automated fluid loading and dispensing system for the deposition of liquid chromatographically separated peptides onto MALDI-TOF MS target plates prior to analysis. MicroFab will commercialize the liquid chromatography microdispensing technology by licensing and/or through the sale of manufacturing systems to major corporations that would manufacture them in volume.
About the Company Based in Plano, Texas, MicroFab Technologies has pioneered digital microdispensing technologies for the past 18 years. MicroFab’s mission is to be the leading global supplier of printing platforms, devices, and services that enable high-payoff applications for microdispensing and precision printing in a wide range of industries. Commercial applications of the technology include microdispensing of electrical and optical polymers, bioactive materials (Proteins, DNA, Reagents), solder, adhesives, and nanoparticle laden fluids. MicroFab Technologies is at www.microfab.com. Contact Dr. David B. Wallace, Vice-President, Technology Development, at info@microfab.com or by phone at 972-578-8076 (ext. 12).
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